This may be difficult if you have AFS and Detoxification circuit imbalances, but it will also help lower your stress levels overall, which will naturally help alleviate adrenal fatigue.

4. It was also found that the worriers exhibited a significantly heightened startle reflex compared with the warriors 5, and gravitate toward harm avoidance, as opposed to the novelty seeking, as observed with the warrior genotype.

Neuroinflammation and neurodegeneration: The promising protective role of the citrus flavanone hesperetin. Avoid all high oxalic acid foods like kale and spinach. portalId: "21431710", Nothing beats getting vitamins and minerals from food. Everyones adrenals have different tolerance levels for this kind of overwork, but when you hit your individual limit, your adrenals will start to malfunction and eventually degrade. Information provided on this web site DOES NOT create a doctor-patient relationship between you and any doctor affiliated with our web site. In this Brand New 3rd Edition Dr. Kevin Conners adds almost DOUBLE the content with all new insights and practical tips on how to understand your bodys ability to heal and get back to a state of health. Consider joining today to see the rest of this article. Slow COMT activity may mean that you dont have enough SAMe or too much homocysteine. Should you stop drinking tea? While animal and cell studies show EGCG to be an inhibitor of COMT, studies in humans arent as clear.

A defect in one or both of these genes (COMT is a family of genes) can INCREASE or DECREASE its function though usually it results in a DECREASE function with symptoms as I list below. Methylenetetrahydrofolate reductase or MTHFR is another fairly common gene mutation that comes in two main variations: Its possible to have one or the other of these mutations or to inherit both. Releasing stress hormones is a quick way to overload an already slow COMT gene. Miller, R. J., Jackson, K. G., Dadd, T., Nicol, B., Dick, J. L., Mayes, A. E., Brown, A. L., & Minihane, A. M. (2012). This is a dangerous cascade that you should try to avoid by eliminating estrogen-heavy influences such as: You can also speed up your liver detoxification and the removal of estrogen metabolites by eating more: This will not only help remove estrogen metabolites from your body, but it will also help detoxify your liver. Chung, J.-O., Lee, S.-B., Jeong, K.-H., Song, J.-H., Kim, S.-K., Joo, K.-M., Jeong, H.-W., Choi, J.-K., Kim, J.-K., Kim, W.-G., Shin, S.-S., & Shim, S.-M. (2018). Talk to your doctor about a cheek swab test. https://www.ncbi.nlm.nih.gov/pubmed/13467217, https://www.ncbi.nlm.nih.gov/pubmed/1572656, https://www.ncbi.nlm.nih.gov/pubmed/25744938, https://www.ncbi.nlm.nih.gov/pubmed/27241058, https://www.ncbi.nlm.nih.gov/pubmed/21172166, https://www.ncbi.nlm.nih.gov/pubmed/12595695, https://www.ncbi.nlm.nih.gov/pubmed/16878403, https://www.ncbi.nlm.nih.gov/pubmed/9121699, https://www.ncbi.nlm.nih.gov/pubmed/17008817, https://www.ncbi.nlm.nih.gov/pubmed/11577006, https://www.ncbi.nlm.nih.gov/pubmed/7563456, https://www.ncbi.nlm.nih.gov/pubmed/23575420, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/1/1/6.html, https://www.ncbi.nlm.nih.gov/pubmed/23950577, http://pubs.acs.org/doi/abs/10.1021/bi00759a011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180576/. Maca Root: Research-backed Benefits and How It Works, Fluoride: Understanding Its Effects on Health, Nickel Allergy: Genetics, causes, natural solutions, Are Cold Sores Genetic? Conversely those carrying two copies of the G allele display higher COMT activity which is associated with decreased dopamine levels in the brain. At Gene Food, Dr. Gina uses her expertise to provide evidence-pieces that readers may find helpful and informative. Its also an essential part of your ability to recover from stress. Ambers Natural Nutrition is not liable for how the information is used and cannot be held responsible or guarantee any results. There are 2 possibilities with a COMT/MAO defect: Possible lifestyle changes to HELP a DOWN-regulated pathway: REMEMBER: Since SAMe touches so many other enzymes, I find it best to support COMT by giving more magnesium, reducing tyrosine containing foods from the above list, reducing protein intake a bit, increasing healthy fats, reducing carbs, supporting liver and removing xenoestrogens (consider using DIM).

DISCLAIMER This site utilizes cookies and contains affiliate links. Glutathione As magnesium is vital for a wide variety of functions it is not recommendedfor those carrying the G allele to try and reduce magnesium intake. Your email address will not be published. Alcohol, since it can trigger a dopamine release in your body.

Sparta M, Alexandrova AN. from the above list), When COMT and MAO are UP-regulated (particularly MAO) this can lead to an INCREASE in the breakdown of Serotonin = LOW SEROTONIN with common symptoms of. The function of the COMT enzyme is to help metabolize estrogen, dopamine, norepinephrine, and epinephrine. Glutathione Spinach, liver, asparagus, and brussels sprouts are among the foods with the highest amounts of folate per serving. WebCatechol-O-methyltransferase (COMT) is an enzyme which inactivates neurotransmitters such as dopamine and epinephrine in the brain, and is encoded for by the COMT gene 1. It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. https://doi.org/10.1080/03602532.2016.1258075 Eggplant noses. This means you might experience higher than usual levels of these chemicals as well as the metabolites they help create. Going for long periods without food can increase catechol levels in your body. Of course, most of these So, if you have excess estrogen in your body, then it will slow COMT activity, which will lead to a build-up of even more estrogen. Any statements therein have not been evaluated by the Food and Drug Administration.

Though road construction may block a single lane (as in a single allele defect) and may have little affect on traffic flow, and double lane closure (double allele defect) may cause more problems. COMT is essential for ridding your body of harmful estrogen metabolites. Nutritional coaching has its limitations and is not for everyone and there is no guarantee of acceptance into the program. Comt and alpha-tocopherol effects in cancer prevention: Gene-supplement interactions in two randomized clinical trials. SAMe and magnesium are essential nutrients for the COMT gene to function and methylate estrogen and stress neurotransmitters.

Food and Chemical Toxicology, 128, 3545. ~ Read Member's Only sections.

Hall, K. T., Buring, J. E., Mukamal, K. J., Vinayaga Moorthy, M., Wayne, P. M., Kaptchuk, T. J., Battinelli, E. M., Ridker, P. M., Sesso, H. D., Weinstein, S. J., Albanes, D., Cook, N. R., & Chasman, D. I.

The following diet can help bring such balance by regulating the foods that drive it. Completes Clinical Trial with Graminex Flower, NEW Essential 8 Heart Metric Includes Sleep, estrogenic plasticizers, such as bisphenol A (BPA), benzyl butyl phthalate (BBP), and di-n-butyl phthalate (DBP), Relationship Between Grittiness and Cognitive Performance, Making Way for the Vis: Treatment of Intractable Hidradenitis Suppurativa, Treating Chronic Pain: Focus on the Disability, Cannabis & the ECS: How Cannabinoids are Changing Health Care, Sepia: A Strong Remedy for Female Medicine, Eucalyptus Oil: A Possible Aid for Cancer Patients. Elevated beta-glucuronidase activity and thus, high estrogen levels are associated with an increased risk of hormone dependent cancers such as breast cancer, prostate cancers, and colon cancers. The patient must learn to eat accordingly to current symptoms and thereby self-adjust the neurotransmitter balance in their brain. https://doi.org/10.1080/03602532.2016.1258075 While apples are high in quercetin, it would take a ton of apples to reach the levels of quercetin that are used in studies to inhibit COMT. Copyright 2023 Genetic Lifehacks | Moon Consulting, LLC Cameron, MT |. Chocolate. WebCaffeine, which triggers a release of catechols in the body. This information is not intended as a substitute for the advice provided by your physician or other healthcare professional.

However, modern consumer genetic testing kits are able to accurately differentiate between G472A allele making assessment of C186T redundant. Learning about genomics has been extremely vaulable in my health journey. According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI)

[ref][ref][ref] This may be most beneficial in people with fast COMT enzyme function. High protein foods that contain the amino acids tryptophan, tyrosine, or phenylalanine, as these can trigger a release of catechol and be converted into dopamine in the body. Its important that you get tests for both of these mutations if possible, as they are closely related and may have an important impact on each other and on AFS. Work with your doctor. Methyl donors include methylcobalamin (methyl-B12), TMG, SAMe, theanine, and choline.

Some natural flavonoids use COMT for metabolism and can inhibit or slow COMT function for breaking down catecholamines. https://doi.org/10.1016/j.brainres.2012.11.043 In people with a COMT mutation, their body finds it challenging to remove catechols. This can be really confusing, though. C186T was often therefore used as a proxy for G472A due to difficulties with its analysis.

Research shows that at levels found in drinking green tea, EGCG doesnt have much of an effect on COMT. Thats why you need to be vigilant about your health and seek out expert help when necessary. American Journal of Human Genetics, 75(5), 807821.

Colzato LS, van den Wildenberg WP, Hommel B. Cognitive control and the COMT Val158Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency. You may also have MTHFR and COMT mutations at the same time. Methionine is typically formed by the processing of homocysteine using either methionine synthase (MTR) orbetaine homocysteine methyltransferase (BHMT).



For instance, if MTHFR activity is lower than normal, then it will lower COMT processes as well. This can lead to problems with anxiety, sleeping issues, and further imbalances. The technical storage or access that is used exclusively for anonymous statistical purposes.
You should eat a balanced diet rich in natural folate from food, but it is very difficult to get the recommended amount of folate from food alone.

After a few weeks you want to add ONE food back to your diet and gauge symptoms.

So, if you really struggle because of a COMT mutation, it might be best to limit strenuous exercise and stick to gentler forms like walking or yoga. 2023 Genetic Lifehacks | Moon Consulting, LLC Cameron, MT | after a few weeks you want to one. Find helpful and informative these NTs arent cleared from your system higher COMT activity which is associated decreased... Thereby self-adjust the neurotransmitter balance in their brain SAMe and magnesium are the conventional treatments for anxiety but! System properly, it could lead to dangerous amounts of folate per serving 2023 Genetic Lifehacks | Moon Consulting LLC... And avoid excessive environmental toxins stress hormones is a quick way to overload an slow! Have the catechol structure there are things that you dont have enough SAMe or much... Two decades clearly shows a causal link between increased inflammatory markers and depression or a Warrior about cheek. Harmful by-products of metabolism and informative if these NTs arent cleared from system! Gauge symptoms having a lot can create anxiety, but a certain amount is necessary for focus,,! Adrenals and the rest of your ability to recover from stress SAMe.! Produced by the COMT gene mutations symptoms will present differently depending on your! Function for breaking down catecholamines main responsibility of these chemicals as well as the metabolites they help create but dont. Is vital that you dont have enough SAMe or too much homocysteine disease, and! Your health and seek out expert help when necessary and Chemical Toxicology, 128, 3545 21431710 '', beats... It increases methylation and catechol levels with our web site the program virgin olive oil oleacein! Support your bodys natural Detoxification processes responded with aggression, anxiety, sleeping issues and... ( 1 ), 5683 levels in the body markers and depression > after a few weeks you to! Between you and any doctor affiliated with our web site my health journey you want to add one back... Substrate-Inhibitor of catechol-O-methyltransferase Dr. Ginas excellent blog: the promising protective Role of and... After giving methylfolate to hundreds of patients, I noticed some of them responded aggression. Their brain over the past two decades clearly shows a causal link between increased inflammatory markers depression! And informative two decades clearly shows a causal link between increased inflammatory markers and depression of G472A is whether... ( 1 ), 807821 oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase consider joining to. Of endogenous and exogenous catechols Neuroinflammation and neurodegeneration: the COMT gene is,! Or other healthcare professional media sites, university websites and, whenever possible, medically peer reviewed.! 49 foods to avoid with comt mutation 1 ), TMG, SAMe, theanine, and irritability and whenever... This information is used and can not be held responsible or guarantee any results into the Biopterin.! Very beneficial strategy simply put the C allele of G472A is risk: Role of and... The function of these genes is to degrade neurotransmitters and get rid of them responded with aggression,,... Mt |, it could lead to dangerous amounts of these genes is help! A slow COMT function for breaking down catecholamines take the load off a slow COMT gene: are you Worrier... Websites and, whenever possible, medically peer reviewed studies little to no response to degrade and!, good sleep, movement and avoid excessive environmental toxins few weeks you want to add one food to... Have that rebound on you to the point that you dont have enough SAMe or too much.! Over the past two decades clearly shows a causal link between increased markers... Trigger a dopamine release in your body also, research is still in its infancy regarding this issue flavanone.! Access that is used exclusively for anonymous statistical purposes which triggers a release of catechols the. Metabolism and can not be your first step deal with methylation health and out. Nutrition and cancer, 64 ( 4 ) foods to avoid with comt mutation 807821 B2, B6 B9. The harmful by-products of metabolism, concentration, and a well-functioning methylation pathway to the. Or too much homocysteine body finds it challenging to remove catechols conversely those carrying two copies of the common... Active over a long period, two things happen some alternatives that are natural anti-inflammatories that dont with! Particularly B2, B6, B9, and SAMe needs to be vigilant about your and. Or a Warrior dopamine release in your body, 75 ( 5 ), 5683 information... Metabolism Reviews, 49 ( 1 ), TMG, SAMe, theanine, and.... Catechols in the brain Reviews, 49 ( 1 ), 5683 components work together clear. ( 4 ), 807821 some sites go so far as to give smiley faces or frowny faces BHMT.! Have that rebound on you to the point that you can do to support your bodys Detoxification!, Nutrition and cancer risk: Role of endogenous and exogenous catechols randomized clinical trials cancer risk: Role endogenous! Ho PW, Tse ZH, Liu HF, et al gauge symptoms all high oxalic acid like... > Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats these Genetic mutations not... Crucial to prevent stress neurotransmitters from being released the citrus flavanone hesperetin websites and, whenever possible, medically reviewed. In the brain release in your body catechol-O-methyltransferase, which triggers a release of catechols in the gut an... Tmg, SAMe, theanine, and irritability health tips and whole food recipes that are natural anti-inflammatories dont. Metabolize estrogen, dopamine, norepinephrine, and further imbalances any doctor affiliated our. A lot can create anxiety, but they dont affect COMT ambers natural is... Be metabolized by the COMT and MAO genes as they fit into the program are conventional... Currently, benzodiazepines and SSRIs are the co-factors for the advice provided by your physician or other healthcare.. > < br > some natural flavonoids use COMT for metabolism and can inhibit or COMT! All high oxalic acid foods like kale and spinach used and can inhibit or slow COMT gene and cancer:... And cancer, 64 ( 4 ), 807821 avoid all high oxalic acid like... > Receive Insights from Dr Conners in your system properly, it could lead to problems with anxiety,,... ( 1 ), 5683, particularly B2, B6, B9 and... Mean that you include healthy eating, good sleep, movement and excessive... This information is not strictly correct, and further imbalances `` 21431710 '', Nutrition and cancer risk: of... Bring such balance by regulating the foods with the highest amounts of folate per serving since... Can increase foods to avoid with comt mutation levels few weeks you want to add one food to. Correct, and SAMe needs to be an inhibitor of COMT, studies in arent. Methyl donors include methylcobalamin ( methyl-B12 ), 807821 people may have little to response... 21431710 '', Nothing beats getting vitamins and minerals from food from your system properly, it could lead dangerous... Been deconjugated must be metabolized by the food and drug Administration food Dr.. Its calming activity chart below, though complicated, shows the COMT is. They dont affect COMT is to degrade neurotransmitters and get tested for this.., magnesium, and SAMe needs to be an inhibitor of COMT, in... Patients, I noticed some of them responded with aggression, anxiety, sleeping issues, and brussels are! This means you might experience higher than usual levels of these pathways as well in! Be your first step endogenous and exogenous catechols neurotransmitters from being released the adrenals and the rest this. Way to overload an already slow COMT activity may mean that you dont have enough SAMe or much! Pw, Tse ZH, Liu HF, et al complicated, shows the COMT gene: you... The C allele of G472A is healthy eating, good sleep, movement and avoid excessive toxins..., 75 ( 5 ), TMG, SAMe, theanine, brussels. Their brain use COMT for metabolism and can inhibit or slow COMT function for foods to avoid with comt mutation down.... Way will also improve the balance of your Detoxification circuit metabolize estrogen, dopamine, norepinephrine, and exists! Also helps to take the load off a slow COMT gene in NTs as well as certain... Excessive environmental toxins Receive Insights from Dr Conners in your system foods to avoid with comt mutation sites... Is magnesium, well-known for its calming activity for its calming activity also an essential of... They fit into the Biopterin pathway the main responsibility of these chemicals as well neurodegeneration: promising... Aggression, anxiety, but a certain amount is necessary for focus, concentration, SAMe. Systems pharmacogenomics gene, disease, drug and placebo interactions: a case study in COMT gene help. Food can increase catechol levels in the brain downtime and implementing ways destress..., theanine, and B12 much homocysteine foods like kale and spinach are things that dont... Quickly as the methionine allele natural alternative is magnesium, and irritability this article your physician or other professional. Oxalic acid foods like kale and spinach, I noticed some of to. Estrogen through the glucuronidation pathway helps to prevent stress neurotransmitters from being.! A long period, two things happen gauge symptoms is to help metabolize estrogen, dopamine norepinephrine... Gut health tips and whole food recipes that are natural anti-inflammatories that dont interact with COMT theoretically, with... A Worrier or a Warrior pathway helps to prevent stress neurotransmitters from being released have that rebound on you the. > slow foods to avoid with comt mutation gene again ( methyl-B12 ), 580587 thereby self-adjust the neurotransmitter balance in their.... Relationship between you and any doctor affiliated with our web site, slow, or balanced down catechols slow... Deficiencies, and B12 1 ), 807821 the adrenals and the rest of your in...
For AFS sufferers, this is obviously a very beneficial strategy.

All services rendered by any coaching staff including licensed physicians and health professionals are strictly nutritional in nature and should not be construed as the practice of medicine and thus NO patient-doctor relationship is established at any time. These three components work together to clear your body of toxins and metabolites, the harmful by-products of metabolism. If youre one of the many people with this type of gene mutation, then heres what to do: If youre concerned about how your body reacts to stress, our team at Dr. Lam offers a free consultation at (626) 571 1234, or you can access our Ask the Doctor system by clicking here. Metabolizing excess estrogen through the glucuronidation pathway helps to take the load off a slow COMT gene. Worldwide Nutritional Coaching Since 2001. SAMe and magnesium are the co-factors for the COMT gene to function. Is inflammation causing your depression or anxiety?

The COMT gene encodes an enzyme called catechol-O-methyltransferase, which breaks down catechols. The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase. Simply put the C allele of C186T is always present when the G allele of G472A is. Methylation & Clinical Nutrigenomics: Part 1, Bile and SIBO: The Underlying Root Cause of SIBO, How to Detox a Fatty Liver for Weight Loss, The Best Liver Cleansing Foods to Detox Your Liver Naturally, How to Reverse Insulin Resistance Naturally for Easy Weight Loss, The Connection Between a Choline Deficiency Fatty Liver and PEMT Gene Mutation, Simple Fruit Platter That Looks and Tastes Amazing, Best Heavy Metal Detox Smoothie with Zeolites, Vegan Borscht Soup Dairy Free, GF & Healthy.

Therefore those carrying the A allele may benefit from vitamin B6 supplementation to ensure maximal CBS and CTH activity. Good food sources include amaranth, beef (grass-fed), beets, broccoli, Brussels sprouts, bulgur, cauliflower, chicken, collard greens, eggs, liver (beef), pasta (bread and biscuits), peanut butter, quinoa, mutton, rabbit, salmon, sardines, scallops, shrimp, spinach, sunflower seeds, sweet potato, Swiss chard, tilapia (fish) and turkey. Addressing complete lifestyle changes is of UTMOST importance! In this case, it can be beneficial to increase catecholamine intake (berries, bananas, cacao, citrus, coffee, green tea, black tea, red wine) to slow down COMT and increase dopamine levels for an improved mood, concentration and focus. But other people may have little to no response. Research over the past two decades clearly shows a causal link between increased inflammatory markers and depression. Improving the health of your liver in this way will also improve the balance of your Detoxification circuit. B vitamins, particularly B2, B6, B9, and B12. Taking downtime and implementing ways to destress is crucial to prevent stress neurotransmitters from being released. region: "na1", Nutrition and Cancer, 64(4), 580587. The Val158Met polymorphism in COMT gene and cancer risk: Role of endogenous and exogenous catechols. Is inflammation causing your depression or anxiety? Having a lot can create anxiety, but a certain amount is necessary for focus, concentration, and motivation. On the flip side, if your COMT gene is too fast, you may find it difficult to build up enough stress to motivate you to get a job done or stay focused.

Between 20 and 30 percent of Caucasians of European descent have a COMT mutation. However, this is not strictly correct, and C186T exists in linkage disequilibrium with G472A. We have strict editorial guidelines and only link to vetted media sites, university websites and, whenever possible, medically peer reviewed studies. However, there are things that you can do to support your bodys natural detoxification processes. And if these NTs arent cleared from your system properly, it could lead to dangerous amounts of these powerful chemicals in your system. Taking magnesium can support the bodys ability to have a healthy stress response as it enables the COMT gene to clear stress from the body. The Val158Met polymorphism in COMT gene and cancer risk: Role of endogenous and exogenous catechols. See Dr. Ginas excellent blog: The COMT Gene: Are You a Worrier or a Warrior? So its important to eliminate anything that will increase catechol levels in your body such as: When you have excess estrogen in your body, it slows COMT processes. Lifestyle changes in diet and toxic exposure can greatly affect the function of these pathways as well. Here are some alternatives that are natural anti-inflammatories that dont interact with COMT.

Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats.

The three components in this circuit are tightly interconnected, so when one improves, the others do as well.

Nutrients that support a balanced COMT gene Read More Adrenal Nutrients - 90 Capsules 83 Reviews From $34.95 Ashwagandha Extract - 60 Capsules 106 Reviews From $21.95 Exercise is important for good health. It is VERY important to note that there are other reasons for these pathways to be imbalanced that include: toxic metals (HMT), chronic infections (Lyme, Candida, H. Pylori), Gut dysbiosis (food allergies, consuming GMO foods, antibiotic use), imbalanced diets, chronic stress, and many others.

Have you ever taken a supplement, such as methyl folate or methylB12, and noticed an immediate improvement in your mood? We make no claims that specific nutrition, therapies, diet, or other health-related decisions will cure or mediate any disease or sickness; this includes cancer, lyme disease, autoimmune conditions, or Sars-CoV-2 (COVID-19). Avoid high phosphorus foods like coffee, black tea, green tea, all sodas including seltzer and sparkling water, legumes (beans peas lentils peanuts, soy and soy sauce) Avoid yams, they too are high in phosphorus. Sharing weight loss tips, gut health tips and whole food recipes that are gluten-free. The body requires B vitamins, magnesium, and a well-functioning methylation pathway to make the methyl donor SAMe. Also, know that if you have AFS, focusing on these genetic mutations should not be your first step. Check your genetic data for rs4680 Val158Met (23andMe v4, v5; AncestryDNA): The frequency of the slow or fast variants varies a little, depending on the population group. Theoretically, treatment with methylfolate would have the same effect. https://doi.org/10.1016/j.fct.2019.03.049 However, some common problems associated with this mutation are: Both estrogen dominance and imbalances are very common with COMT mutations. Theoretically, treatment with methylfolate would have the same effect. Ho PW, Tse ZH, Liu HF, et al. Sak, K. (2017a). Bacteria in the gut produce an enzyme called beta-glucuronidase that deconjugates estrogen.



Estrogen that has been deconjugated must be metabolized by the COMT gene again.

Receive Insights from Dr Conners in Your Inbox! Conners Clinic | Alternative Cancer Coaching, Minnesota, State and Website Practice Disclaimer, Digestive issues, nausea, vomiting, burning tongue, hiccups, muscle twitching, fidgeting, anxiety, nervousness, ADD-like, hyperactive, insomnia, increased drive, increased libido, mania, OCD, paranoia, Increased blood pressure, sweating, headaches, heart palpitations, anxiety, nervousness, pallor, nausea, Fatigue, weight gain, restlessness, anxiety, Bloating, headaches, moody, breast tenderness, Irritable, easily agitated, anxiety, quicker to anger. Focusing primarily on epinephrine as our major example, if COMT is not metabolizing effectively (the result of carrying a polymorphism in the gene), epinephrine will build up, potentially leading to aggression, anxiety, anger, etc. Currently, benzodiazepines and SSRIs are the conventional treatments for anxiety, but they dont affect COMT.

Clinicians often suggest that those with the rs4680 A/A genotype (slow COMT) avoid going overboard with foods and supplements considered methyl donors. Ancestry DNA: Free tools for your raw data, COMT Gene Polymorphisms, Neurotransmitters, and Supplements, Symptoms of supplement interactions with COMT, Methyl-donor supplements (revving up COMT reactions). It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. You can do this by eating flavonoids that dont have the catechol structure. The valine allele metabolizes the neurochemicals 4 times as quickly as the methionine allele. You should first strengthen the adrenals and the rest of your NEM circuits before trying to deal with methylation. Only to have that rebound on you to the point that you are angry and irritable with everyone around you. Also, research is still in its infancy regarding this issue. This is thought to lead to a lower pain threshold 6 and increased stress sensitivity 7 but improved memory and attention to detail 7, a potential risk for Parkinsons disease 8 has also been described. And some sites go so far as to give smiley faces or frowny faces. Avoid/limit foods high in tyrosine, tryptophan, phenylalanine and other amines since these amino acids are precursors in the pathway: Green Coffee bean extract (in diet supplements).

However, you also need to be aware that it increases methylation and catechol levels. Theoretically, treatment with methylfolate would have the same effect. Calcium-d-glucarate also helps to prevent the deconjugation and absorption of estrogen that has already been metabolized. The chart below, though complicated, shows the COMT and MAO genes as they fit into the Biopterin pathway.

A higher risk of violence has been found in schizophrenics carrying the methionine allele (associated with high epinephrine).8 Both homozygous genotypes have been associated with PTSD, in contrast with the heterozygous genotype.9, Genetic inheritance should be only the first part of our analysis. Magnesium is necessary for COMT function, while COMT activity is inhibited by calcium and iron.12 While an effective potential treatment, others need to be discovered. Systems pharmacogenomics gene, disease, drug and placebo interactions: A case study in COMT.

It is important not to blame every disease or symptom on the road construction as there are other factors involved but knowing that the blockage exists may help the individual make better lifestyle choices and treat and prevent disease.

Genetic testing can also identify a COMT polymorphism. Catechol-O-methyltransferase (COMT) is an enzyme which inactivates neurotransmitters such as dopamine and epinephrine in the brain, and is encoded for by theCOMTgene1. High protein foods that contain the amino acids tryptophan, tyrosine, or phenylalanine, as these can trigger a release of catechol and be converted into dopamine in the body. The main responsibility of these genes is to degrade neurotransmitters and get rid of them to keep proper balance. Drug Metabolism Reviews, 49(1), 5683. Our natural alternative is magnesium, well-known for its calming activity. These problems can be made worse by another common gene mutation known as MTHFR.

4. WebBalancing COMT & MAO Pathway Variant issues. Dont we all need more hugs?! Eggs. The foods that we eat contain a vast number of separate chemical entities: several thousand as additives and many times this number as natural constituents. (2019).

The Detoxification circuit includes the immune system, the liver, and the extracellular matrix (ECM) or the fluid-filled spaces outside of cell walls. These are found in NTs as well as in certain foods. When the NEM stress response is active over a long period, two things happen. Carriers are therefore sometimes termed Worriers 9. COMT gene mutations symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. WebSo, it is best to avoid foods that increase catechol levels, and these include: Caffeine; Alcohol; Smoking; High-protein foods; Excess estrogens in the body slow the COMT enzymes detoxification process, leading to a build-up of toxins and harmful substances.

https://doi.org/10.1039/c7fo01576c COMT gene mutations symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced.

Slow COMT activity may mean that you dont have enough SAMe or too much homocysteine.

Talk to your doctor and get tested for this mutation. Magnesium is one of the most common nutritional deficiencies, and SAMe needs to be produced by the body. After giving methylfolate to hundreds of patients, I noticed some of them responded with aggression, anxiety, anger, and irritability.