It may cause side effects such as: Dizziness. New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. Its best to check with your doctor about the dosage, based on the symptoms you have and other possible conditions, prior to taking either pine bark extract or Pycnogenol. Pycnogenol alleviated adverse effects in cancer patients, Pycnogenol improved working memory in older adults, Pycnogenol lowered the use of analgesic drugs in dysmenorrhea (severe menstrual pain), Pycnogenol reduced symptoms in endometriosis comparable to leuprorelin, the standard drug for this condition, Pycnogenol was found to be effective for sun-caused hyperpigmented skin, Pycnogenol reduced the inflammation in lupus patients, Pycnogenol reduced gingival bleeding and plaque formation. The dosage in most clinical studies varied between 50-360 mg/day. 4. ( 1) 2. The specific tree from which the bark is extracted is called a maritime pine. Benefits, Nutrition, Uses & How It Compares vs. Blackberries. It comes from the bark of a European pine tree. While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. Another 2006 study examined the effects of the antioxidant activity of pine bark extract on oxidative stress, which is thought to be one of the nongenetic factors contributing to ADHD. However, its unclear how clinically effective Pycnogenol is for most of these conditions due to the low quality of evidence. Perimenopausal women who took pine bark extract for eight weeks noticed decreased cholesterol and triglyceride levels. A trial of 84 people found that both Pycnogenol oral supplements and creams (0.5%) may prevent hemorrhoids from bleeding during acute attacks after 7 days. Regardless of what youre using it for, its best to start with the lowest possible dose. This can cause pain, especially in areas of the body that are used repeatedly, like your hands, fingers, and knees. For allergies: 50 milligrams twice daily. Pycnogenol and Pine Bark Extract Supplements. Lowers Blood Pressure. You can find out your systolic blood pressure by looking at the top number of a blood pressure test. Organika Pycnogenol 50mg 50 Tablets . Add to Cart. They include: We need more research to know for sure if pycnogenol helps treat these conditions. Here are the many health benefits believed to be possible with Pycnogenol: Now lets dive into the first condition it could help treat. In a clinical trial of 92 people with tinnitus, or ringing in the ears, Pycnogenol (100-150 mg/day) helped reduce symptoms and improve blood flow in the ears after 4 weeks [80]. The list goes on a bit further, as the OPCs in thisextract may inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems, which basically means it may be a natural treatment for many serious health conditions, such as stroke and heart disease. The women taking Pycnogenol also experienced improvement in fatigue, sleep, concentration, memory, dizziness, and mood, including less irritability. Its true. Pycnogenol has given indications that it might be able to benefit heart and artery health, to include reducing high blood pressure. Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. . Pycnogenol can help control blood pressure, which helps improve overall heart health. A 2017 review reported on the many benefits of using pine bark extract to reduce the effects of aging on skin. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Abdominal pain was by far the most . Pine bark extract has been studied with regard to its ability to help diabetic patients. 10 Ways to Control Blood Sugar without Medication, Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies, Reduces leaky blood vessels by making the wall proteins (collagen, elastin) more resistant to damage, Helps maintain high vitamin C and E blood levels for their antioxidant effects, Inhibits platelet aggregation like low-dose aspirin, Reduces hardening in the arteries by increasing nitric oxide production in blood vessels, leading to greater dilatation, Counteracts the damaging effects of ultraviolet radiation, Stimulates the immune system by boosting T and B cell functions, Protects brain cells from toxic chemicals. The supplement significantly reduced hot flashes, night sweats, mood swings, irregular periods, loss of libido, and vaginal dryness. Regardless, a natural option is available and far worth the wait. A popular variety is the pinus maritime or the maritime pine that grows exclusively along the coast of southwest France. In the control group, there were five thrombotic events; whereas the Pycnogenol-treated subjects only experienced nonthrombotic, local flare-ups. According to the lab results of 10 volunteers, a higher Pycnogenol dose (300 mg) may impact these enzymes after just 30 minutes [52]. Another clinical trial of 76 people with allergic asthma also suggests that Pycnogenol may reduce IgE antibodies and asthma symptoms [18, 16]. Finally, research suggests that Pycnogenol may improve triathlon time while possibly reducing cramps and post-running pain [10]. But, as you know, going for the natural approach can make a huge difference in overall health. Pycnogenol is officially extracted from the French maritime pine (Pinus pinaster), which grows in the southwest coast of France. She is a strong advocate of integrating scientific knowledge and holistic medicine. Clinical research suggests that Pycnogenol is possibly effective for improving athletic performance. The study suggests it may increase desire, arousal, lubrication, orgasm, satisfaction and reduce pain [70]. In a study of 72 children undergoing cancer chemotherapy, Pycnogenol reduced painful mouth ulcers, both alone and in combination with vitamin E [79]. Too much pressure signals that your heart might be working too hard. - Apply a hot compress to the anus or soaking it in a shallow tub of hot water several times a day. For asthma in children: 1 milligram per pound of body weight given in two divided doses. Can Pycnogenol help? Cigarette smoking increases platelet aggregation. Top 9 Natural Allergy Relief Home Remedies - Dr. Axe 1 week ago from draxe.com Eat an Anti-Inflammatory, Alkaline Diet. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25]. Grape seed extract may have heart-health benefits. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. Considering that about 1 of 3 adults in the U . (8). Its quality is specified in the United States Pharmacopeia [3]. 5. (2017). A clinically studied blend of Pycnogenol and a special bilberry extract (called Mirtogenol ) has been shown to provide benefits for vision and eye health. It can then lead to heart problems like stroke or heart attack. Twenty-one patients were given Pycnogenol at 150 mg daily and 18 patients received no treatment for a period of eight weeks. Thirty patients were treated with 150 mg of Pycnogenol a day and the other 10 patients with placebo for a period of two months. In the placebo group, the retinopathy worsened; whereas, in the Pycnogenol-treated group, there was no deterioration. While these results are promising, there isnt enough research to fully understand the effect of antioxidant levels on ADHD symptoms. Note that the numbers in parentheses (1, 2, etc.) Extracts can also be made from other pine barks, such as Pinus radiata, Pinus densiflora, Pinus thunbergii, and Pinus massoniana. Grape seed extract may be more beneficial for those who are obese. Pycnogenol is known under different names in some countries, such as Oligopin, and Flavangenol in Japan [4, 5]. Once youre sure that you dont have any negative reactions, you may be able to increase your dosage according to the label. Arginine is a non-essential amino acid because most humans can make it in their bodies. It also may help regenerate and maintain vitamin C and E levels while also potentially increasing nitric oxide levels, which may relax and protect blood vessels [1]. Research indicates that Pycnogenol provides an increase in survival performance of train athletes. Make sure to seek out the advice of your physician prior to using pine bark extract or the branded name, Pycnogenol. Rating: 100%. Chemistry. There's good evidence that pycnogenol helps with eye damage caused by diabetes. It may cause side effects such as: Risks. Circulation and Jet Lag on Long Flights. However, these studies appear to be methodologically sound and reliable, with no blatant errors in the study design and data collection. Some people seek to manage ADHD symptoms through an ADHD diet. (10), A 15-year Dutch study was published stating that 27,939 healthy female health professionals were given aspirin or a placebo for a period of time. Purity and potency of Pycnogenolare continuously monitored . For children with ADHD, research suggests that symptoms start to return after about a month without taking maritime pine, so taking periodic breaks shouldnt make it any less effective. Interactions. All rights reserved. Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. $47.99. In 1535, a French explorer by the name of Jacques Cartier found himself ice-bound on the St. Lawrence River. For diseases of the retina, including those related to diabetes: 50 milligrams three times daily. A 2011 study by Dr. G. Belcaro concluded, " Pycnogenol administration was effective for better control of signs and symptoms of allergic asthma and reduced the need for medication". Forty patients were treated with either 600 mg chestnut seed extract a day or 360 mg Pycnogenol a day over a period of four weeks. 11 Skin elasticity increased, and skin fatigue decreased significantly in this study as well, further lowering the wrinkling risk. There were 88 in the control group and 81 in the Pycnogenol group. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. The crew fell extremely ill from scurvy, an extreme lack of vitamin C. Cartiers crew crossed paths with a Quebec Indian who encouraged them to drink a tea made from pine bark and needles. A total of 40 patients with retinopathy (damage to the retina part of the eye) from diabetes and other vascular causes were enrolled in one study. Pycnogenol is a substance taken from the pine bark of trees found in the southwest region of France. $31.99. Learn about all the potential benefits of Pycnogenol and find out which ones are most supported by science. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. Help your body fight the effects of normal aging. A good-quality study was conducted in 77 diabetic patients who received their standard antidiabetic treatment along with 100 mg Pycnogenol a day or placebo for 12 weeks. The . It has many health benefits, and may help protect against several chronic conditions. A trial of 86 people with eye damage from diabetes found that antioxidant therapy (including pycnogenol, vitamin E, and Coenzyme Q10) may improve eye health and reduce reactive oxygen species levels [35]. (2006). Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). Dr. Steven Lamm did a great job at explaining the new benefits of pycnogenol. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. But two months ago, erectile dysfunction health food with the help of the Divine Tool Alliance, the price of all materials related to the puppet mechanism was raised by 20 erectile dysfunction health food 30 , and the price of selling the puppet was reduced by 10. So it . In a double-blind, placebo-controlled, randomized, crossover study, 50 patients with erectile dysfunction (ED) were treated with either L-arginine plus Pycnogenol or placebo for a month. Pycnogenol is the leading ingredient in Isotonix OPC-3, Market America's best-. A high number signals high blood pressure. In one trial of 77 people with type 2 diabetes, pycnogenol (100 mg/day) for 12 weeks lowered both blood sugar levels and HbA1c, a marker of long-term blood glucose levels [31]. DOI: Dvorkov M, et al. Skin irritation. In one study, 200 mg a day of Pycnogenol taken three hours prior to the first cigarette for the day for two months significantly reduced cigarette-induced platelet aggregation. The active ingredients in pycnogenol can also be extracted from other sources, including peanut skin, grape seed, and witch hazel bark. A trial of 132 people found that Pycnogenol (150 mg/day) may improve risk factors of metabolic syndrome including lowering triglyceride levels, blood pressure, and fasting glucose, decreasing waist circumference, and increasing HDL cholesterol levels [29]. They were given Pycnogenolfor a period of 10 days. Some small studies suggest it may also protect against coronary artery disease and blood clots. Ginkgo biloba has been widely cultivated across the globe for a variety of uses, most of which are medicinal. Pycnogenol French maritime pine bark extract acts as a potent blend of antioxidants, it is a natural anti-inflammatory, stimulates generation of collagen and hyaluronic acid and help with natural dilation of blood vessels by supporting production of nitric oxide. The first studied group included 66 healthy subjects in whom the number of muscle cramps was recorded two weeks before entering the study and during the fourth and fifth week. Diabetic retinopathy is a type of eye injury caused by complications from diabetes. If possible, try to get pine bark extract from a local supplier, such as a health food store. A combination supplement (pycnogenol with collagen, coenzyme Q10, and other ingredients) reduced skin aging, elasticity, hydration, and tonicity in a study of 30 women [65]. Helps maintain high vitamin C and E blood levels for their antioxidant effects. Another study of 47 women found that supplementing with 30 mg Pycnogenol twice daily for over 1 month may reduce menstrual pain [73]. We don't yet know what the best dose to use is, but studies have used two 50 mg Pycnogenol capsules per day. In the Pycnogenol-treated group, blood sugar levels were significantly lowered as compared to those not on Pycnogenol. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial. Animal studies have found that gotu kola makes it harder . This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. 3. Natural Factors Pycnogenol 100mg 30 Veggie Caps. Interesting activities, new dishes in restaurants, specialty ingredients, explanations of some netizens questions, etc.Hu Xuan is even helping Fatty s company s tourism manager, managing with Vice President Du Meixin, such as arranging guests reasonably.By the way.Dad, I want to tell you something.I plan to invest in the hotels and entertainment centers in the . Various brands of pycnogenol are available. What gives pine bark extract its notoriety as a powerful ingredient and super antioxidant is that its loaded with oligomeric proanthocyanidin compounds, OPCs for short. DOI: Trebatick J, et al. Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. There are also several other natural ADHD remedies you can try. But the actual bioavailability of this complex mixture is still unknown. Higher doses (200 mg/day) may improve blood vessel health and function after 8 weeks according to a study of 23 people with heart disease [38]. The Benefits of DIM. In the following sections, well discuss the common forms and dosages of Pycnogenol that are commercially available. (2004). 5) Vein Diseases and Swelling. Its been noted that taking OPCs and vitamin C supplements at the same time could increase blood pressure if you have hypertension. Researchers suggest that Pycnogenol may reduce cough, night-awakenings, improve airway flow, and the need for additional asthma medication [16]. (11, 12), While both eliminate pain, the pine bark extract is a far better choice. WebMD does not provide medical advice, diagnosis or treatment. All of our content is written by scientists and people with a strong science background. Tongkat ali is an herbal remedy suggested to treat various ailments, including low testosterone and male infertility. It also reduced the size of scars. A review was conducted of French maritimepine bark extract, specifically using the nutritional supplement Pycnogenol. SelfDecode is a personalized health report service, Disease of the retina in the eye. Although the preliminary studies show many health benefits with the use of Pycnogenol, future larger and better studies are needed. Another one of its exemplary effects is helping manage blood pressure levels. Four hundred years later, a French researcher named Jacques Masquelier did some studies to understand why this natural remedy was so effective. Thirty patients with diabetic ulcers were treated with 150 mg Pycnogenol daily for four weeks and another group of 30 comparable patients received no treatment. Ask your doctor for advice. Joe Cohen flipped the script on conventional and alternative medicine and it worked. In those treated with Pycnogenol, the edema score was increased by 17.9% versus an increase of 58.3% in the control group. 5 6 However, evidence is conflictingother studies have shown no effect on the same measures. Add to Cart. It seems to lower blood pressure and improve blood flow to the legs. 40 years of research has been dedicated to establishing the safety of Pycnogenol and its benefits for human health. Commonly called arthritis, osteoarthritis is caused when the cartilage on your joints begins to wear down. Studies have found that supplementing with pycnogenol effectively strengthens the blood vessels, stabilizing blood pressure. A randomized placebo-controlled trial of 60 children with mild-to-moderate asthma found that those who took Pycnogenol may be able to reduce or discontinue their use of rescue inhalers more often than the placebo group [15]. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. In 24 people with early eye damage from diabetes, Pycnogenol improved vision, reduced eye swelling, and improved circulation in the eye after 2 months. Its used as a natural supplement for several conditions, including dry skin and ADHD. It should never be used as a replacement for approved medical therapies. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. SelfDecode does not treat, diagnose or cure any conditions, Our goal is to not have a single piece of inaccurate information on this website. He later extracted proanthocyanidins from the European coastal pine tree, which he named Pycnogenol.. However, some of these other pine bark extracts can have different active compounds, which may affect their biological activity. Berberine is a compound extracted from several plants. ", American Heart Association: Understanding Blood Pressure Readings., Iranian Journal of Public Health: "Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis. Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common . SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. A Pycnogenol combination product (with l-arginine, alpha lipoic acid, B vitamins, and vitamin K2) may help protect the blood vessels and reduce high homocysteine levels, according to a trial of 25 people [39]. Two studies illustrate the possibilities: One was a randomized, double-blind, placebo-controlled, crossover study in which 26 asthmatic patients were given either a maximum of 200 mg a day of Pycnogenol or placebo for the first period of four weeks and then crossed over to the alternate treatment for the next four weeks. You can learn more about how we ensure our content is accurate and current by reading our. (4). Another highlight of grapes nutrition is the presence of polyphenols, which have been shown to decrease chronic inflammation. Researchers from the study suggest that low Pycnogenol dosage and short study duration may explain the lack of benefits [44]. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. We believe that the most accurate information is found directly in the scientific source. Staves Off Infections. from the bark of the French maritime pine tree. In one human study, some of the reported side effects of chanca piedra supplementation included: abdominal pain. Depending on the extraction process and the source Pinus species used (P. radiata or P. pinaster), the exact composition will vary. Your email address will not be published. Pycnogenol may have benefits for heart and artery health. ( 4) Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Low-dose Pycnogenol (30 mg/day) may reduce pain in pregnant women, particularly hip, joint, lower back, groin, and calf cramps in the third trimester [71]. Infants and children may not be able to synthesize enough of it, but it is present in many protein-rich . We do not aim to diagnose, treat, cure or prevent any illness or disease. Pycnogenol French maritime pine bark extract's 4 basic properties. after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. This review noted that pine bark extract may also help with: In addition to its skin-healing properties, pine bark extract also shows promise for helping children manage ADHD symptoms. During the first month on L-arginine, only five percent of patients experienced normal erection. As a skin powder, however, you can use it safely for up to six weeks. Tell your doctor about any supplements you're taking, even if they're natural. It also lessened the amount of asthma medication they needed. (2013). Pycnogenol is the registered trademark name for a French formula. One study involved a four-week treatment period followed by one week of no treatment or observation period. Pycnogenol is not approved by the FDA for medical use. Eye health. Erectile dysfunction has increased over the past decade or two, creating a pathway for various medications to land on the shelves of numerous medicine cabinets. Vertigo. DOI: Gulati OP. Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease caused primarily by tobacco use. Studies have also safely used Pycnogenol in children and during pregnancy. Along with the rest of the crew, he developed symptoms of vitamin-C deficiency. Enzogenol, a slightly different pine bark extract, improved cognitive function in a clinical trial of 42 older men after 5 weeks of supplementation [23]. Rare cases of liver disease. In the study, many of the participants on Pycnogenol reduced their dosage of high-blood-pressure medication (nifedipine) [37]. In patients with chronic venous insufficiency, the number of muscle cramps decreased from 6.3 to 2.6; in athletes from 8.6 to 2.4. They could interact with medicines to suppress the immune system, chemotherapy drugs, and blood thinners. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. The most effective blood sugar-lowering dose was 200 mg/day higher doses had no further benefit [33]. In a good-quality study, 77 patients with osteoarthritis were treated with 100 mg of Pycnogenol daily and 79 patients were treated with placebo for three months. During week, five without, treatment, reduction of cramps was maintained in all three groups. Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. A new peer-reviewed study, published in the Bratislava Medical Journal, shows that daily supplementation with the natural antioxidant, Pycnogenol, a French maritime pine bark extract, can improve the symptoms of ED.. Pain score in the Pycnogenol-treated group was reduced by 56%, as compared to 9.6% reduction in the placebo group. If you are taking blood thinners, do not take pine bark extract or Pycnogenol unless approved by your doctor. Pycnogenol may reduce glucose levels, but it doesnt appear to increase insulin production or insulin sensitivity. Some studies have suggested it may modestly improve blood pressure, cholesterol, and C-reactive protein. whole-body health. Possible side effects . A study of 32 people with heart failure lasting 12 weeks suggests that a combination of Pycnogenol with CoQ10 (PycnoQ10) may improve blood pressure, heart function, edema, and capacity for physical activity [40]. Who doesnt want amazing skin? Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. According to some researchers, Pycnogenol may lower blood pressure by relaxing blood vessels, reducing free radicals, and lowering inflammation. Memorial Sloan-Kettering Cancer Center web site: "About Herbs: Pine Bark Extract. Side effects. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. It can also be found as creams, lotions or ointments, typically containing 0.5 percent to 2 percent pine bark extract. Consider pine bark extract through a conversation with your physician or a functional medicine doctor. This supplement may also increase muscle endurance and performance after a single pre-exercise dose according to a study of 9 cyclists [12, 13]. But a month after pycnogenol was stopped, the symptoms came back, suggesting that it may need to be used regularly to achieve the benefits [41]. There havent been any studies looking at long-term liver damage. Studies have found that when taken along with an inhaler, Pycnogenol can reduce leukotrienes, helping to relieve lung inflammation and limit frequency of inhaler use., Many people develop osteoarthritis as they age. Another study found this supplement can even halt progression of vision . Pycnogenol (up to 200 mg/day) may improve asthma and reduce inflammatory asthma markers in the blood, leukotrienes, after 4 weeks, according to a randomized placebo-controlled trial of 26 asthma patients [14].
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