Inactive ingredients: cellulose, corn starch, docusate sodium View Complete Details Get Latest Price Request a quote M/S Om Shree Navajeevan Medicines XANAX Tablets (alprazolam) are indicated for the management of anxiety disorder (a condition corresponding most closely to the APA Diagnostic and Statistical Manual [DSM-III-R] diagnosis of generalized anxiety disorder) or the short-term relief of symptoms of anxiety. Save my name, email, and website in this browser for the next time I comment. With anxiety, anxiety, the initial daily dose is 0.75-1.5 mg Xanax and can be increased to 3-4.5 mg / day. kidney or liver disease (especially alcoholic liver disease); What is the most important information I should know about XANAX XR? WebThe second dose of the vaccine should be given as close to the minimum recommended schedule of 21 days (for Pfizer) or 28 days (for Moderna) as possible. Neonates born to mothers using benzodiazepines during the later stages of pregnancy have been reported to experience symptoms of sedation and neonatal withdrawal [see Warnings and Precautions (5.4), Clinical Considerations)]. This product's labeling may have been updated. Preston Mcelheney This drug belongs to a class of drugs called benzodiazepines. Alprazolam is in a class of medications called benzodiazepines. (, The use of benzodiazepines, including XANAX XR, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. There is positive evidence of human fetal risk during pregnancy. Instruct patients that discontinuation or dosage reduction of XANAX XR may require a slow taper [see Warnings and Precautions (5.3), Drug Abuse and Dependence (9.3)]. In patients with hepatic impairment, the recommended starting dosage of XANAX XR is 0.5 mg once daily. This boosts the activity of a chemical called gamma-aminobutyric acid (GABA). WebWomen's Health. In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months [see Drug Abuse and Dependence (9.3)]. You may report side effects to FDA at 1-800-FDA-1088. Ava is a sensor bracelet that tracks your vital signs such as skin temperature and pulse to track your health and send real-time data to the platform. If the clinical response after switching is inadequate, titrate the dosage as outlined above. Doses are selected depending on the severity of the syndrome, the individual sensitivity of the patient and his reaction to the drug. Instruct patients to inform their healthcare provider if they are pregnant or intend to become pregnant during treatment with XANAX XR [see Warnings and Precautions (5.4)]. Serious side effects including coma and death have happened in people who have abused or misused benzodiazepines, including XANAX XR. Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH. (8.2). Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Some patients may prove resistant to all discontinuation regimens. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to XANAX XR during pregnancy. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. Abuse is the intentional, non-therapeutic use of a drug, even once, for its desirable psychological or physiological effects. As in all cases of drug overdosage, respiration, pulse rate, and blood pressure should be monitored. There have also been reports of withdrawal seizures upon rapid decrease or abrupt discontinuation of Xanax [see Warning and Precautions (5.2), Drug Abuse and Dependence (9.3)]. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Each XANAX XR extended-release tablet, for oral administration, contains 0.5 mg, 1 mg, 2 mg, or 3 mg of alprazolam. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation, and intravenous access. WebAlprazolam 2mg Xanax Bars 2mg, Pfizer, 50"tab, Treatment: Anxiety,Antidepression 1,500/ Bottle Of 500 mL Get Latest Price Alprazolam is used to treat anxiety disorders and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Acute withdrawal signs and symptoms associated with benzodiazepines have included abnormal involuntary movements, anxiety, blurred vision, depersonalization, depression, derealization, dizziness, fatigue, gastrointestinal adverse reactions (e.g., nausea, vomiting, diarrhea, weight loss, decreased appetite), headache, hyperacusis, hypertension, irritability, insomnia, memory impairment, muscle pain and stiffness, panic attacks, photophobia, restlessness, tachycardia, and tremor. -Swelling of your face, lips, tongue, or throat. Increased digoxin concentrations have been reported when alprazolam was given, especially in geriatric patients (>65 years of age). Set id: aa58fff3-c297-49be-838b-599c32ad9835, WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS; ABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS. WebXanax Alprazolam 1 mg Tablet Bottle 100 Tablets CIV Pfizer 00009009001. Use of XANAX XR, particularly in patients at elevated risk, necessitates counseling about the risks and proper use of XANAX XR along with monitoring for signs and symptoms of abuse, misuse, and addiction. Consequently, appropriate precautions (e.g., limiting the total prescription size and increased monitoring for suicidal ideation) should be considered in patients with depression. 2. The molecular formula is C17H13ClN4 which corresponds to a molecular weight of 308.76. No evidence of carcinogenic potential was observed in rats or mice administered alprazolam for 2 years at doses up to 30 and 10 mg/kg/day, respectively. Approximately 17% of the 531 patients who received XANAX XR in placebo-controlled clinical trials for panic disorder had at least 1 adverse event that led to discontinuation compared to 8% of 349 placebo-treated patients. a history of drug or alcohol addiction; or Advise women not to breastfeed during treatment with XANAX XR [see Use in Specific Populations (8.2)]. Keep XANAX XR in a safe place and away from children. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Data from in vitro studies of alprazolam suggest a possible drug interaction of alprazolam with paroxetine. Alprazolam exposure was not meaningfully affected in the presence of ritonavir. Xanax XR is used in the treatment of panic disorder and belongs to the drug class benzodiazepines . Its also available as a generic drug. XANAX XR extended-release tablets are available as: XANAX XR is contraindicated in patients: Concomitant use of benzodiazepines, including XANAX XR, and opioids may result in profound sedation, respiratory depression, coma, and death. Carbamazepine: The oral clearance of alprazolam (given in a 0.8 mg single dose) was increased from 0.900.21 mL/min/kg to 2.130.54 mL/min/kg and the elimination T1/2 was shortened (from 17.14.9 to 7.71.7 hour) following administration of 300 mg per day carbamazepine for 10 days [see Drug Interactions (7.2)]. Drugs demonstrated to be CYP3A inhibitors on the basis of clinical studies involving alprazolam: nefazodone, fluvoxamine, and cimetidine [see Drug Interaction (7.1), Clinical Pharmacology (12.3)]. Although early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted. The extent of exposure (AUC) and elimination half-life (t) were not affected by eating. BioNTech and Pfizer are testing a freeze-dried version that would not need ultracold storage. Alprazolam AUC and Cmax was reduced by 12% and 16%, respectively, in the presence of ritonavir. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Abrupt discontinuation or rapid dosage reduction of benzodiazepines or administration of flumazenil, a benzodiazepine antagonist, may precipitate acute withdrawal reactions, including seizures, which can be life-threatening. Physician Prescribing Information and Patient Information on this page may no longer be current. It is supplied by Pfizer U.S. Pharmaceuticals Group. Tolerance to the therapeutic effect of XANAX XR may develop; however, little tolerance develops to the amnestic reactions and other cognitive impairments caused by benzodiazepines. Required fields are marked *. 4 yr. ago Damn, whats up with all the downvotes? Its a type of benzodiazepine that is usually prescribed to people dealing with anxiety disorders. The dosage of Xanax pills ranges from 0.25 milligrams to 3.5 milligrams. Take XANAX XR exactly as your healthcare provider prescribed. trouble saying words clearly (dysarthria), Store XANAX XR at room temperature between 68F to 77F (20C to 25C). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. Users who take Xanax report feeling the following effects: A calming sensation Feelings -Memory problems Thanks, Your email address will not be published. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage. Fertility. 1 line going down the center of the 2. for Healthcare professionals: XANAX U.S. In either case, it is presumed that the prescribed dose is not sufficient to maintain plasma levels above those needed to prevent relapse, rebound, or withdrawal symptoms over the entire course of the interdosing interval. Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use. Other common Xanax side effects include: Difficulty speaking Problems with coordination You and your healthcare provider should decide if you should take XANAX XR while you are pregnant. XANAX Tablets contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. i am honestly leaving my review its good experience with this website. WebAlprazolam 2mg Xanax Bars 2mg, Pfizer, 50"tab, Treatment: Anxiety,Antidepression 1,500/ Bottle Of 500 mL Get Latest Price Alprazolam is used to treat anxiety disorders and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). In panic disorders 0.5 mg 3 times a day, the daily dose can reach 3-6 mg, the highest daily dose 10 mg. Other studied drugs include: Cimetidine: Coadministration of cimetidine increased the maximum plasma concentration of alprazolam by 82%, decreased clearance by 42%, and increased T1/2 by 16%. These are not all the possible side effects of XANAX XR. for Healthcare professionals: XANAX U.S. WebXanax is the single most prescribed psychiatric drug in the United States; belongs to the benzodiazepines group of drugs. out. (of a stimulus or mental process) below the threshold of sensation or consciousness; perceived by or affecting someones mind without their being aware of it. Monitor neonates exposed to benzodiazepines during pregnancy and labor for signs of sedation, respiratory depression, withdrawal, and feeding problems and manage accordingly [see Warnings and Precautions (5.4)]. Your healthcare provider will tell you how much XANAX XR to take and when to take it. Manifestations of alprazolam overdosage include somnolence, confusion, impaired coordination, diminished reflexes, and coma. The sale and distribution of Xanax outside the U.S. does not comply with the regulations of the Food and Drug Administration (FDA) for the safe use of this medication. Occasional patients required as much as 10 mg per day. Thanks, Live Search Today, Excellent service & has all the products I need to purchase, always arrives on time. Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages (i.e., higher and/or more frequent doses) and those who have had longer durations of use [see Warnings and Precautions (5.3)]. It may harm them. Abrupt discontinuation or rapid dosage reduction of XANAX XR after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures), In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months, Table 1: Adverse Reactions Leading to Discontinuation in 1% of XANAX XR-treated Patients and at least twice the Rate of Placebo-treated Patients in Placebo-Controlled Trials, General disorders/administration site conditions, Table 2: Adverse Reactions Occuring in 1% in XANAX-treated Patients and Greater than Placebo-treated Patients in 6 and 8 week Placebo-Controlled Trials Panic Disorder, Injury, poisoning, and procedural complications, Musculoskeletal and connective tissue disorder, Respiratory, thoracic, and mediatinal disorders, General disorders and administration site conditions, Musculoskeletal and connective tissue disorders, Respiratory, thoracic, and mediastinal disorders, Table 3: Discontinuation-Emergent Symptom Incidence Reported in 5% of XANAX XR-treated Patients and at least twice the Rate of Placebo-treated Patients in Short-Term, Placebo-Controlled Trials, Respiratory, thoracic and mediastinal disorders, Musculosketal and connective tissue disorders. It is composed of nucleoside-modified mRNA (modRNA) encoding a mutated form of the full-length spike protein of SARS-CoV-2, which is encapsulated in lipid nanoparticles. WebA white Xanax bar contains 2 mg in one whole pill, but can easily be split into four different segments. A class of drugs is a group of medications that work in a similar way. Physician Prescribing Information. ( 1) DOSAGE AND ADMINISTRATION Recommended starting oral dosage is 0.5 mg to 1 mg once daily (preferably in the morning). for Delivering my pill. Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death. If XANAX XR is used for periods longer than 8 weeks, the healthcare provider should periodically reassess the usefulness of the drug for the individual patient. As of 30 March 2021, Pfizer and BioNTech aimed to manufacture about 2.5billion doses in 2021. Xanax is used to treat anxiety disorders and anxiety caused by depression. Controlled trials of XANAX XR for the treatment of panic disorder included dosages in the range of 1 mg to 10 mg per day. Death has been reported in association with overdoses of alprazolam by itself, as it has with other benzodiazepines. Imipramine and Desipramine: The steady state plasma concentrations of imipramine and desipramine have been reported to be increased an average of 31% and 20%, respectively, by the concomitant administration of XANAX in doses up to 4 mg per day. 1 BOTTLE 50 TABS, 2 BOTTLES 100 TABS, 4 BOTTLES 200 TABS, 6 BOTTLES 300 TABS, 8 BOTTLES 400 TABS, Your email address will not be published. The use of benzodiazepines, including XANAX XR, exposes users to the risks of abuse, misuse, and addiction, which can lead to overdose or death. In addition, there were two 8-week, fixed-dose, placebo-controlled studies of XANAX XR in adult patients with panic disorder, involving fixed XANAX XR doses of 4 mg and 6 mg once per day that did not show a benefit for either dose of XANAX XR. There have been reports of death in patients with severe pulmonary disease shortly after the initiation of treatment with alprazolam. Buy high quality steroids online. Physical dependence is not the same as drug addiction. you are allergic to alprazolam, other benzodiazepines, or any of the ingredients in XANAX XR. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage (a patient-specific plan should be used to taper the dose) [see Dosage and Administration (2.3)]. (5.2) Abrupt discontinuation or rapid dosage reduction of XANAX after -Impaired coordination Pharmacists can take an active role in preventing counterfeit drugs by ensuring that they source products only from a reputable wholesaler or distributor. Swallow tablets whole; do not divide, crush, or chew. A parent or legal guardian must complete the online registration on the CVS website or Minuteclinic.com for minors up to age 17. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. (, Recommended total daily dosage is 3 mg to 6 mg daily. The longer-term efficacy of XANAX XR has not been systematically evaluated. Xanax is a powerful Benzodiazepine that is often prescribed to treat generalized anxiety disorder (GAD), panic disorders, and insomnia. 2 mg. 100 Tablets Rx only. In 2020, 52% of the companys revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Physician Prescribing Information. Both types of white Xanax pills are manufactured by Pfizer. I never even stated that the pills are real pharmaceutical grade. Alprazolam is in a class of medications called benzodiazepines. The reported relative potencies in benzodiazepine receptor binding experiments and in animal models of induced seizure inhibition are 0.20 and 0.66, respectively, for 4-hydroxyalprazolam and -hydroxyalprazolam. WebPfizer Xanax Packaging & Bottle. Xanax is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia). The most common events leading to discontinuation and considered to be drug-related (i.e., leading to discontinuation in at least 1% of the patients treated with XANAX XR at a rate at least twice that of placebo) are shown in Table 1. The pharmacokinetic parameters at steady-state for the two hydroxylated metabolites of alprazolam (4-hydroxyalprazolam and -hydroxyalprazolam) were similar for XANAX and XANAX XR, indicating that the metabolism of alprazolam is not affected by absorption rate. Their half-lives appear to be similar to that of alprazolam. The elimination T1/2 was prolonged (30 hours versus 13 hours). Dispense in tight (USP), light-resistant, child-resistant containers. The maximum recommended dosage is 4 mg daily (in divided doses). Do not drive, operate heavy machinery, or do other dangerous activities until you know how XANAX XR affects you. Sorry, you need to enable JavaScript to visit this website. In addition, the 1 mg and 3 mg tablets contain D & C yellow No. The structural formula is represented below: Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH. WebXanax is the single most prescribed psychiatric drug in the United States; belongs to the benzodiazepines group of drugs. Vaccination requires two doses given three weeks apart. Distribution and storage is a logistical challenge because the vaccine needs to be stored at extremely low temperatures. Limit dosage and duration of XANAX XR during concomitant use with CNS depressants. XANAX XR passes into your breast milk and may harm your baby. Begin with minimal doses of Xanax xr (0.25-0.5 mg / day), followed by a rise first in the evening and then in the daytime. It is not known if XANAX XR is safe and effective in the treatment of panic disorder for use longer than 8 weeks. Limited data from published literature reports the presence of alprazolam in human breast milk. The effects of alprazolam on lactation are unknown. Elderly and weakened patients 0.25 mg 2-3 times a day. Alprazolam also comes as a solution. Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death [see Drug Abuse and Dependence (9.2)]. Before taking this medicine WebThe U.S. The 2-mg dose of alprazolam in a Xanax bar is a heavy dose of the drug. Xanax is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia). Both types of white Xanax pills are manufactured by Pfizer. Though Xanax does have legitimate medical uses, some people abuse it or take it recreationally. (, Neonatal Sedation and Withdrawal Syndrome (NOWS): Use of XANAX XR during pregnancy can result in neonatal sedation and neonatal withdrawal syndrome. Thanks usamedzone.com I never even stated that the pills are real pharmaceutical grade. The PfizerBioNTech COVID-19 vaccine (tozinameran), sold under the brand name Comirnaty, is an mRNA-based COVID-19 vaccine developed by the German company BioNTech. (, Concomitant use with strong cytochrome P450 3A (CYP3A) inhibitors, except ritonavir. WebXANAX (alprazolam) This product information is intended only for residents of the United States. Maximal concentrations and T1/2 of alprazolam are approximately 15% and 25% higher in Asians compared to Caucasians. Compared to morning dosing, alprazolam Cmax increased by 30% and the Tmax decreased by an hour following dosing at night. and the best Part is there customer support. Buy Medications in the Bulk Quantity fromusamedzone.com. Please let me know where you got your design. 9/11 Reckoning: Deconstructing the Deception, Wuhan Institute of Virology - Ralph S. Baric (Gain-of-function Researcher), Nazi Germany - Hitler's Residence (The Inalco House, Argentina), JFK - Howard Brennan (Assassination Witness), Wuhan Institute of Virology - Shi Zhengli (Lead Researcher), Nazi Germany - Reinhard Heydrich (Principal Architect of the Holocaust), The JFK Assassination (1963): The Truth Revealed, Pizzagate - Deep State Child Sex-Trafficking & Pedophilia, Pizzagate - Heavy Breathing (Amanda Kleinman). Following long term treatment of ritonavir (> 10 14 days), CYP3A4 induction offsets this inhibition. Patients who are currently being treated with divided doses of XANAX may be switched to XANAX XR at the same total daily dose taken once daily. The efficacy of XANAX XR in the treatment of panic disorder in adults was established in two 6-week, flexible-dose, placebo-controlled studies in adult patients meeting DSM-III criteria for panic disorder. inside, 2-3 times a day, regardless of food intake. For the same reason, patients should be cautioned about the concomitant use of alcohol and other CNS depressant drugs during treatment with XANAX XR [see Drug Interactions (7.1)]. The extended-release drug is only used to treat panic disorder. Protect from light. See the end of this Medication Guide for a complete list of ingredients in XANAX XR. Flumazenil may be useful in situations when an overdose with a benzodiazepine is known or suspected. WebThis product information is intended only for residents of the United States. Had a duplicate order which was rectified almost upon receipt of email to customer care .then I had it delivered super fast . Closely monitor patients with impaired respiratory function. Most of the interactions that have been documented with alprazolam are with drugs that modulate CYP3A4 activity. Anxiety Disorders McKesson Shop Products Shop by Category Pfizer #00009009001; Xanax Alprazolam 1 mg Tablet Bottle 100 Tablets CIV XANAX, TAB 1MG (100/BT) CIV. Each segment is meant to be a single 0.5 mg dose of Xanax. Reproductive Health. Other common Xanax side effects include: Difficulty speaking Problems with coordination In patients on digoxin therapy, measure serum digoxin concentrations before initiating XANAX XR. You should not breastfeed while taking XANAX XR. To make sure Xanax is safe for you, tell your doctor if you have: seizures or epilepsy;